2 1/2 pounds eye of round roast
3/4 cup ketchup
3/4 cup apple juice — or white wine
1 tablespoon brown sugar
1/2 teaspoon ground cumin
1/2 teaspoon dried oregano
1/8 teaspoon cayenne
1 tablespoon soy sauce
Spray a dutch oven with Pam. Heat over medium high heat until hot. Add roast; cook 4-6 minutes, turning to brown evenly.
Combine ketchup & remaining ingredients. Pour over roast & cover tightly. Bake at 325 F for 2 1/2 hours or until roast is tender. To serve, slice roast thinly; arrange on serving platter. Spoon sauce over slices.